Here is workflow to enable OOO on different users.
1. Exchange Management Console (EMC)
=> Login to the Exchange Control Panel
=> Mail => Options => select Another User.
=> Select the user for whom you want to configure Automatic Reply.
=> Once a user is selected a new IE page opens & you can see a notification saying ” Admin is working on behalf of Usera@domain.com) => click “Tell people you’re on vacation”
=> Select “Send AutomaticReplies” => Select the date & enter the OOF message => Click Save.
=> Select appropriate option if you want the OOF to be sent to users outside the organization => “select automatic reply messages to senders outside my organization” select => “Send replies to all external senders”=> enter the OOF message & save.
2. Exchange Management Shell (EMS):
Set-MailboxAutoReplyConfiguration user@domain.xxx –AutoReplyState Scheduled –StartTime “1/4/2015″ –EndTime 5/4/2015″ –ExternalMessage “External OOF message content” –InternalMessage “Internal OOF message content”.
verify autoreply settings single user
Get-MailboxAutoReplyConfiguration username
3. How to disable OOO single user
Set-MailboxAutoReplyConfiguration user@domain.xxx –AutoReplyState Disabled –ExternalMessage $null –InternalMessage $null
http://msexchangeguru.com/2015/03/30/automatic-replies/